Transforming Growth Factor (TGF)-β1 Internalization
نویسندگان
چکیده
منابع مشابه
transforming growth factor β1 (tgf-β1) in the sera of postmenopausal osteoporotic females
conclusions our study demonstrated that tgf-β1 serum levels is higher in osteoporotic postmenopausal females than non-osteoporotic ones, and probably aberrant increase in tgf-β1 in postmenopausal females can result in uncoupled bone resorption and formation, which leads to osteoporosis. background postmenopausal osteoporosis is a major cause of morbidity in postmenopausal females. transforming ...
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Cancer cells secreting excess latent TGF-β are often resistant to TGF-β induced growth inhibition. We observed that RNAi against TGF-β1 led to apoptotic death in such cell lines with features that were, paradoxically, reminiscent of TGF-β signaling activity and that included transiently enhanced SMAD2 and AKT phosphorylation. A comprehensive search in Hela cells for potential microRNA drivers o...
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Abstract: Background and Aim: The increasing incidence of infertility is alarming. About 10-30% of infertility are classified as Unexplained Infertility (UI) which is not an absolute clinical condition. TGF-b1 is multifunctional cytokine and produced mainly by T regulatory (Treg) lymphocytes. This cytokine plays important roles in physiology of normal pregnancy. The association of Single...
متن کاملTransforming Growth Factor β1 (TGF-β1) in the Sera of Postmenopausal Osteoporotic Females
BACKGROUND Postmenopausal osteoporosis is a major cause of morbidity in postmenopausal females. Transforming growth factor β1 (TGF-β1) and interleukin 18 (IL-18) play complex roles in normal bone metabolism, and in pathophysiology of postmenopausal osteoporosis. OBJECTIVES The aim of this study was to design an analytic cross sectional study in order to further clarify the role of TGF-β1 and ...
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BACKGROUND TGF-β1 (transforming growth factor-β1) importantly contributes to cardiac fibrosis by controlling differentiation, migration, and collagen secretion of cardiac myofibroblasts. It is still elusive, however, to which extent TGF-β1 alters the electrophysiological phenotype of myofibroblasts and cardiomyocytes and whether it affects proarrhythmic myofibroblast-cardiomyocyte crosstalk obs...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m100033200